R Packages Nix Binary Cache
Reproducible binary cache for all CRAN and Bioconductor packages with weekly updates.
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Professional Summary
I am a clinican scientist and board-certified neurologist with a research focus on neuroimmunology, data analysis and single-cell transcriptomics. I work at the Department of Neurology, University Hospital Münster.
Programming/DevOps Skills
- R ★★★★★
- Linux Admin ★★★☆☆
- Nix ★★★☆☆
- Docker ★★★☆☆
- Git ★★★☆☆
- Python ★★☆☆☆
- C++ ★☆☆☆☆
Interests
Data analysis
Neuroimmunology
Single cell transcriptomics
Projects
Human PNS Atlas
Multi-omic characterization of human sural nerves across polyneuropathies.
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1 min read
CerebroAppLite
R package that provides an interactive visualization of single cell RNA-seq data.
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1 min read
Featured Publications
Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies
Diseases affecting multiple peripheral nerves, termed polyneuropathies (PNPs), are common, mechanistically heterogeneous, and their causes are challenging to identify. Here, we …
michael-heming
Atlas of cerebrospinal fluid immune cells across neurological diseases.
OBJECTIVE: Cerebrospinal fluid (CSF) provides unique insights into the brain and neurological diseases. However, the potential of CSF flow cytometry applied on a large scale …
michael-heming
Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma
BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a rare lymphoma of the central nervous system, usually of diffuse large B cell phenotype. Stereotactic biopsy …
michael-heming
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges.
Based on single-cell transcriptomics, we here identify a highly location-specific composition and expression profile of tissue-resident leukocytes in CNS border compartments …
david-schafflick
Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid
We utilized single-cell sequencing and examined the immune cell profiles from the cerebrospinal fluid of Neuro-COVID patients and discovered an expansion of dedifferentiated …
michael-heming
Recent Publications
(2025).
Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies.
Nature Communications.
(2025).
Extracorporeal therapy procedures (plasma exchange and immunoadsorption) in chronic inflammatory demyelinating polyneuropathies (CIDP)- a database analysis..
BMC Neurology.
(2025).
Anti-BCMA CAR-T cell therapy in relapsed/refractory chronic inflammatory demyelinating polyneuropathy..
Med.
(2025).
Single-Cell Transcriptomics Identifies a Prominent Role for the MIF-CD74 Axis in Myasthenia Gravis Thymus..
Neurology(R) neuroimmunology & neuroinflammation.
(2025).
Atlas of cerebrospinal fluid immune cells across neurological diseases..
Annals of Neurology.
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