Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma
Sep 24, 2022
Stroke induces disease-specific myeloid cells in the brain parenchyma and pia
We deeply characterize tissue-resident leukocytes in meninges and brain parenchyma and discover that leukocytes respond differently to stroke depending on their site of residence. We thereby discover a unique phenotype of myeloid cells exclusive to the brain after stroke. These stroke-associated myeloid cells partially resemble neurodegenerative disease-associated microglia. They are mainly of resident microglial origin, partially conserved in humans and exhibit a lipid-phagocytosing phenotype. Blocking markers specific for these cells partially ameliorates stroke outcome thus providing a potential therapeutic target.
Feb 1, 2022
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges.
Based on single-cell transcriptomics, we here identify a highly location-specific composition and expression profile of tissue-resident leukocytes in CNS border compartments featuring B cells and their progenitors in the dura as an unexpected site of B cell residence.
Jul 1, 2021
Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid
We utilized single-cell sequencing and examined the immune cell profiles from the cerebrospinal fluid of Neuro-COVID patients and discovered an expansion of dedifferentiated monocytes and exhausted CD4+ T cells.
Jan 1, 2021
Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity.
Apr 1, 2020
Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
Jan 1, 2020